Successful trials with human subjects have been conducted. For example, a Fall 1999 article from the University of Alabama at Birmingham states: "Microbiologist Suzanne Michalek, Ph.D. ( 64 ), and pediatric dentist Noel Childers, D.D.S., Ph.D., have developed an anti cavity vaccine that is being administered to volunteers in a nasal spray rather than in a hypodermic needle. In Winter 2005, Dr. Michaleck replied to an email request for an update, saying "Regarding our study, we had very encouraging results that the vaccine significantly delayed the re colonization of the bacterium that causes tooth decay. We are very excited about our findings and are continuing our studies." In response to follow up questions: "We have been doing human trial studies with our various vaccine candidates. ... The delayed colonization was months without a boost.
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